A Quantitative LC-MS/MS Method for the Detection of 16 Synthetic Cathinones and 10 Metabolites and Its Application to Suspicious Clinical and Forensic Urine Samples.

ABSTRACT:

Background

Synthetic cathinones currently represent one of the most predominant (sub)-classes of new psychoactive substance (NPS) in illicit drug markets. Despite the increased concerns caused by the constant introduction of new analogues, these drugs are not commonly assayed in routine drug testing procedures and may not be detected in standard screening procedures. This study presents a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the detection and quantification of 16 synthetic cathinones and 10 metabolites in human urine.

Methods

The method was validated for all analytes using published guidelines. The evaluated parameters achieved acceptable values according to the set criteria. Potential abuse of synthetic cathinones was investigated i

SUBMITTER: Aldubayyan AA 

PROVIDER: S-EPMC9145040 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature