Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system.

ABSTRACT:

Background

The cytokine interleukin-6 (IL-6) modulates a variety of inflammatory processes and, context depending, can mediate either pro- or anti-inflammatory effects. Excessive IL-6 signalling in the brain is associated with chronic inflammation resulting in neurodegeneration. Strawberry notch homolog 2 (Sbno2) is an IL-6-regulated gene whose function is largely unknown. Here we aimed to address this issue by investigating the impact of Sbno2 disruption in mice with IL-6-mediated neuroinflammation.

Methods

Mice with germline disruption of Sbno2 (Sbno2^-/-) were generated and crossed with transgenic mice with chronic astrocyte production of IL-6 (GFAP-IL6). Phenotypic, molecular and transcriptomic analyses were performed on tissues and primary cell cultures to cla

SUBMITTER: Syme TE 

PROVIDER: S-EPMC9145108 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature