Proteomic alteration of endometrial tissues during secretion in polycystic ovary syndrome may affect endometrial receptivity.

ABSTRACT: Embryo implantation is a complex developmental process that requires coordinated interactions among the embryo, endometrium, and the microenvironment of endometrium factors. Even though the impaired endometrial receptivity of patients with polycystic ovary syndrome (PCOS) is known, understanding of endometrial receptivity is limited. A proteomics study in three patients with PCOS and 3 fertile women was performed to understand the impaired endometrial receptivity in patients with PCOS during luteal phases. Through isobaric tags for relative and absolute quantitation (iTRAQ) analyses, we identified 232 unique proteins involved in the metabolism, inflammation, and cell adhesion molecules. Finally, our results suggested that energy metabolism can affect embryo implantation, whereas inflammati

SUBMITTER: Li J 

PROVIDER: S-EPMC9145147 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature