CD8⁺ T Cells in OA Knee Joints Are Differentiated into Subsets Depending on OA Stage and Compartment.

ABSTRACT: Osteoarthritis (OA) is no longer considered a purely degenerative disease. OA is defined as a disease of the entire joint, in which inflammation occurs in various joint tissues. The overall aim of this study was to analyze the presence and polarization of CD8⁺ T cell subsets in OA knee joints, in relation to the OA stage and compartment (synovial fluid (SF), synovial membrane (SM,) peripheral blood (PB)). A quantitative flow analysis of CD8⁺ T cell subsets to compare the SF, SM, PB, was performed in patients with different stages of OA (early, unicondylar and bicondylar OA). Samples of the SF, SM and PB were harvested from a total of 55 patients at the time of surgery. Early OA was confirmed by independent surgeons intraoperatively. Uni- and bicondylar OA was confirme

SUBMITTER: Platzer H 

PROVIDER: S-EPMC9145354 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature