Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas.

ABSTRACT: The poly(A) tail at the 3' end of mRNAs determines their stability, translational efficiency, and fate. The shortening of the poly(A) tail, and its efficient removal, triggers the degradation of mRNAs, thus, regulating gene expression. The process is catalyzed by a family of enzymes, known as deadenylases. As the dysregulation of gene expression is a hallmark of cancer, understanding the role of deadenylases has gained additional interest. Herein, the genetic association network shows that CNOT6 and CNOT7 are the most prevalent and most interconnected nodes in the equilibrated diagram. Subsequent silencing and transcriptomic analysis identifies transcripts possibly regulated by specific deadenylases. Furthermore, several gene ontologies are enriched by common deregulated genes. Given the p

SUBMITTER: Kyritsis A 

PROVIDER: S-EPMC9145511 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature