Non-B, Non-C Hepatocellular Carcinoma in an HBV- and HCV-Endemic Area: A Community-Based Prospective Longitudinal Study.

ABSTRACT: A large community cohort of adults who participated in a health screening program from 2003 to 2013 were prospectively analyzed for the risk factors of non-B, non-C (NBNC) hepatocellular carcinoma (HCC). The serostatus of hepatitis B and C of 52,642 participants was linked to the mortality and cancer registration data of the Health and Welfare Data Science Center, Ministry of Health and Welfare, Taiwan. During a median follow-up of 6 years, 35 of the 43,545 participants who were negative for both HBsAg and anti-HCV antibody developed HCC. Multivariate Cox regression analysis revealed that old age (hazard ratio, 95% CI: 1.058, 1.019-1.098, p = 0.003); male sex (2.446, 1.200-4.985, p = 0.014); high aspartate aminotransferase levels (6.816, 2.945-15.779, p < 0.001); fi

SUBMITTER: Chang TS 

PROVIDER: S-EPMC9145519 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature