Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results.

ABSTRACT: With the abundance of chemicals in the environment that could potentially cause neurodevelopmental deficits, there is a need for rapid testing and chemical screening assays. This study evaluated the developmental toxicity and behavioral effects of 61 chemicals in zebrafish (Danio rerio) larvae using a behavioral Light/Dark assay. Larvae (n = 16-24 per concentration) were exposed to each chemical (0.0001-120 μM) during development and locomotor activity was assessed. Approximately half of the chemicals (n = 30) did not show any gross developmental toxicity (i.e., mortality, dysmorphology or non-hatching) at the highest concentration tested. Twelve of the 31 chemicals that did elicit developmental toxicity were toxic at the highest concentration only, and thirteen chemicals were devel

SUBMITTER: Jarema KA 

PROVIDER: S-EPMC9145655 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature