Epigenetic Effect of Maternal Methyl-Group Donor Intake on Offspring's Health and Disease.

ABSTRACT: Maternal exposure to some dietary and environmental factors during embryonic development can affect offspring's phenotype and, furthermore, the risk of developing diseases later in life. One potential mechanism responsible for this early programming may be the modification of the epigenome, such as DNA methylation. Methyl-group donors are essential for DNA methylation and are shown to have an important role in fetal development and later health. The main goal of the present review is to summarize the available literature data on the epigenetic effect (DNA methylation) of maternal methyl-group donor availability on reproductivity, perinatal outcome, and later health of the offspring. In our literature search, we found evidence for the association between alterations in DNA methylation patte

SUBMITTER: Bokor S 

PROVIDER: S-EPMC9145757 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature