NK Cells Acquire CCR5 and CXCR4 by Trogocytosis in People Living with HIV-1.

ABSTRACT: NK cells play a major role in the antiviral immune response, including against HIV-1. HIV-1 patients have impaired NK cell activity with a decrease in CD56^dim NK cells and an increase in the CD56^-CD16⁺ subset, and recently it has been proposed that a population of CD56⁺NKG2C⁺KIR⁺CD57⁺ cells represents antiviral memory NK cells. Antiretroviral therapy (ART) partly restores the functional activity of this lymphocyte lineage. NK cells when interacting with their targets can gain antigens from them by the process of trogocytosis. Here we show that NK cells can obtain CCR5 and CXCR4, but barely CD4, from T cell lines by trogocytosis in vitro. By UMAP (Uniform Manifold Approximation and Projection), we show that aviremi

SUBMITTER: Vo DN 

PROVIDER: S-EPMC9145773 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature