Post-Translational Modifications of Histones Are Versatile Regulators of Fungal Development and Secondary Metabolism.

ABSTRACT: Chromatin structure is a major regulator of DNA-associated processes, such as transcription, DNA repair, and replication. Histone post-translational modifications, or PTMs, play a key role on chromatin dynamics. PTMs are involved in a wide range of biological processes in eukaryotes, including fungal species. Their deposition/removal and their underlying functions have been extensively investigated in yeasts but much less in other fungi. Nonetheless, the major role of histone PTMs in regulating primary and secondary metabolisms of filamentous fungi, including human and plant pathogens, has been pinpointed. In this review, an overview of major identified PTMs and their respective functions in fungi is provided, with a focus on filamentous fungi when knowledge is available. To date, most of

SUBMITTER: Etier A 

PROVIDER: S-EPMC9145779 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature