The Search for Cryptic L-Rhamnosyltransferases on the Sporothrix schenckii Genome.

ABSTRACT: The fungal cell wall is an attractive structure to look for new antifungal drug targets and for understanding the host-fungus interaction. Sporothrix schenckii is one of the main causative agents of both human and animal sporotrichosis and currently is the species most studied of the Sporothrix genus. The cell wall of this organism has been previously analyzed, and rhamnoconjugates are signature molecules found on the surface of both mycelia and yeast-like cells. Similar to other reactions where sugars are covalently linked to other sugars, lipids, or proteins, the rhamnosylation process in this organism is expected to involve glycosyltransferases with the ability to transfer rhamnose from a sugar donor to the acceptor molecule, i.e., rhamnosyltransferases. However, no obviou

SUBMITTER: Mora-Montes HM 

PROVIDER: S-EPMC9145935 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature