Water-Soluble, Alanine-Modified Fullerene C₆₀ Promotes the Proliferation and Neuronal Differentiation of Neural Stem Cells.

ABSTRACT: As carbon-based nanomaterials, water-soluble C₆₀ derivatives have potential applications in various fields of biomedicine. In this study, a water-soluble fullerene C₆₀ derivative bearing alanine residues (Ala-C₆₀) was synthesized. The effects of Ala-C₆₀ on neural stem cells (NSCs) as seed cells were explored. Ala-C₆₀ can promote the proliferation of NSCs, induce NSCs to differentiate into neurons, and inhibit the migration of NSCs. Most importantly, the Ala-C₆₀ can significantly increase the cell viability of NSCs treated with hydrogen peroxide (H₂O₂). The glutathioneperoxidase (GSH-Px) and superoxide dismutase (SOD) activities and glutathione (GSH) content increased significantly in NSCs treated even b

SUBMITTER: Ren H 

PROVIDER: S-EPMC9146176 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature