Brain Proteome and Behavioural Analysis in Wild Type, BDNF^+/- and BDNF^-/- Adult Zebrafish (Danio rerio) Exposed to Two Different Temperatures.

ABSTRACT: Experimental evidence suggests that environmental stress conditions can alter the expression of BDNF and that the expression of this neurotrophin influences behavioural responses in mammalian models. It has been recently demonstrated that exposure to 34 °C for 21 days alters the brain proteome and behaviour in zebrafish. The aim of this work was to investigate the role of BDNF in the nervous system of adult zebrafish under control and heat treatment conditions. For this purpose, zebrafish from three different genotypes (wild type, heterozygous BDNF^+/- and knock out BDNF^-/-) were kept for 21 days at 26 °C or 34 °C and then euthanized for brain molecular analyses or subjected to behavioural tests (Y-maze test, novel tank test, light and dark test, social preference test

SUBMITTER: Maffioli E 

PROVIDER: S-EPMC9146406 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature