Association of Human Intestinal Microbiota with Lifestyle Activity, Adiposity, and Metabolic Profiles in Thai Children with Obesity.

ABSTRACT:

Background

Dysbiosis of intestinal microbiota may be linked to pathogenesis of obesity and metabolic disorders.

Objective

This study compared the gut microbiome of obese Thai children with that of healthy controls and examined their relationships with host lifestyle, adiposity, and metabolic profiles.

Methods

This cross-sectional study enrolled obese children aged 7-15. Body composition was evaluated using bioelectrical impedance analysis. Stool samples were analyzed by 16S rRNA sequencing using the Illumina MiSeq platform. Relative abundance and alpha- and beta-diversity were compared with normal-weight Thai children from a previous publication using Wilcoxon rank-sum test and ANOSIM. Relationships of gut microbiota with lifestyle activity, body composition, and meta

SUBMITTER: Visuthranukul C 

PROVIDER: S-EPMC9146442 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature