M2-Macrophage-Derived Exosomes Promote Meningioma Progression through TGF-β Signaling Pathway.

ABSTRACT: Tumor-associated macrophages (TAMs) have been shown to be an essential component of the tumor microenvironment and facilitate the proliferation and invasion of a variety of malignancies. However, the contribution of TAMs to meningioma progression has not been characterized in detail. In this study, we aimed to discover a novel regulatory pathway by which exosome-mediated M2-polarized macrophages participate in meningioma tumorigenesis and progression. Methods. First, the distribution and functional phenotype of macrophages in meningioma tissues were assessed by immunohistochemistry. Macrophage-derived exosomes (MDEs) were characterized, and further cell coculture experiments were performed to explore the effects of M2-MDEs on the proliferation, migration, and invasion of meningioma

SUBMITTER: Fu XH 

PROVIDER: S-EPMC9146444 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature