New Quinoline-Urea-Benzothiazole Hybrids as Promising Antitubercular Agents: Synthesis, In Vitro Antitubercular Activity, Cytotoxicity Studies, and In Silico ADME Profiling.

ABSTRACT: A series of 25 new benzothiazole-urea-quinoline hybrid compounds were synthesized successfully via a three-step synthetic sequence involving an amidation coupling reaction as a critical step. The structures of the synthesized compounds were confirmed by routine spectroscopic tools (¹H and ¹³C NMR and IR) and by mass spectrometry (HRMS). In vitro evaluation of these hybrid compounds for their antitubercular inhibitory activity against the Mycobacterium tuberculosis H₃₇Rv pMSp12::GPF bioreporter strain was undertaken. Of the 25 tested compounds, 17 exhibited promising anti-TB activities of less than 62.5 µM (MIC₉₀). Specifically, 13 compounds (6b, 6g, 6i-j, 6l, 6o-p, 6r-t, and

SUBMITTER: Moodley R 

PROVIDER: S-EPMC9146500 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature