Homo/Hetero-Dimers of Aromatic Bisabolane Sesquiterpenoids with Neuroprotective Activity from the Fungus Aspergillus versicolor A18 from South China Sea.

ABSTRACT: Chromatographic fractionation of the EtOH extracts of the marine-derived fungus Aspergillus versicolor A18 has led to the isolation of 11 homo/hetero-dimers of aromatic bisabolane sesquiterpenoids including eight diphenyl ether-coupled aromatic bisabolanes (1a/1b and 5-10) and three homodimers (2-4), together with their monomers including three aromatic bisabolanes (11-13) and two diphenyl ethers (14 and 15). Their structures and absolute configurations were elucidated by extensive spectroscopic analysis including HRESIMS, 1D/2D NMR, calculated ECD, and the optical rotatory data. Among the four new compounds, (+/-)-asperbisabol A (1a/1b), asperbisabol B (2), and asperbisabol C

SUBMITTER: Weng HZ 

PROVIDER: S-EPMC9146609 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature