Better Estimation of Spontaneous Preterm Birth Prediction Performance through Improved Gestational Age Dating.

ABSTRACT: The clinical management of pregnancy and spontaneous preterm birth (sPTB) relies on estimates of gestational age (GA). Our objective was to evaluate the effect of GA dating uncertainty on the observed performance of a validated proteomic biomarker risk predictor, and then to test the generalizability of that effect in a broader range of GA at blood draw. In a secondary analysis of a prospective clinical trial (PAPR; NCT01371019), we compared two GA dating categories: both ultrasound and dating by last menstrual period (LMP) (all subjects) and excluding dating by LMP (excluding LMP). The risk predictor's performance was observed at the validated risk predictor threshold both in weeks 19^1/7-20^6/7 and extended to weeks 18^0/7-20^6/7. Strict blinding a

SUBMITTER: Burchard J 

PROVIDER: S-EPMC9146613 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature