Senecavirus A Enhances Its Adaptive Evolution via Synonymous Codon Bias Evolution.

ABSTRACT: Synonymous codon bias in the viral genome affects protein translation and gene expression, suggesting that the synonymous codon mutant plays an essential role in influencing virulence and evolution. However, how the recessive mutant form contributes to virus evolvability remains elusive. In this paper, we characterize how the Senecavirus A (SVA), a picornavirus, utilizes synonymous codon mutations to influence its evolution, resulting in the adaptive evolution of the virus to adverse environments. The phylogenetic tree and Median-joining (MJ)-Network of these SVA lineages worldwide were constructed to reveal SVA three-stage genetic development clusters. Furthermore, we analyzed the codon bias of the SVA genome of selected strains and found that SVA could increase the GC content of the thir

SUBMITTER: Zhao S 

PROVIDER: S-EPMC9146685 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature