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Anti-Inflammatory Polyketides from an Alga-Derived Fungus Aspergillus ochraceopetaliformis SCSIO 41020.

ABSTRACT: A new linear polyketide, named aspormisin A (1), together with five known polyketides (2-6), were isolated from the alga-derived fungus Aspergillus ochraceopetaliformis SCSIO 41020. Their structures were elucidated through a detailed comprehensive spectroscopic analysis, as well as a comparison with the literature. An anti-inflammatory evaluation showed that compounds 2, 5, and 6 possessed inhibitory activity against the excessive production of nitric oxide (NO) and pro-inflammatory cytokines in LPS-treated RAW 264.7 macrophages in a dose-dependent manner without cytotoxicity. Further studies revealed that compound 2 was active in blocking the release of pro-inflammatory cytokines (IL-6, MCP-1, and TNF-α) induced by LPS both in vivo and in vitro. Our findings provide a basis for the further development of linear polyketides as promising anti-inflammatory agents.

SUBMITTER: Chen C

PROVIDER: S-EPMC9146786 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Anti-Inflammatory Polyketides from an Alga-Derived Fungus Aspergillus ochraceopetaliformis SCSIO 41020.

Chen Chunmei C Ren Xue X Tao Huaming H Cai Wenteng W Chen Yuchi Y Luo Xiaowei X Guo Peng P Liu Yonghong Y

Marine drugs 20220427 5

A new linear polyketide, named aspormisin A (1), together with five known polyketides (2-6), were isolated from the alga-derived fungus Aspergillus ochraceopetaliformis SCSIO 41020. Their structures were elucidated through a detailed comprehensive spectroscopic analysis, as well as a comparison with the literature. An anti-inflammatory evaluation showed that compounds 2, 5, and 6 possessed inhibitory activity against the excessive production of ni ...[more]

PMID: 35621946

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