Spectroscopy Approach for Highly-Efficient Screening of Lectin-Ligand Interactions in Application for Mannose Receptor and Molecular Containers for Antibacterial Drugs.

ABSTRACT: Rational search of a ligand for a specific receptor is a cornerstone of a typical drug discovery process. However, to make it more "rational" one would appreciate having detailed information on the functional groups involved in ligand-receptor interaction. Typically, the 3D structure of a ligand-receptor complex can be built on the basis of time-consuming X-ray crystallography data. Here, a combination of FTIR and fluorescence methods, together with appropriate processing, yields valuable information about the functional groups of both the ligand and receptor involved in the interaction, with the simplicity of conventional spectrophotometry. We have synthesized the "molecular containers" based on cyclodextrins, polyethyleneimines (PEI) or spermine with mannose-rich side-chains of different

SUBMITTER: Zlotnikov ID 

PROVIDER: S-EPMC9146875 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature