Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces.

ABSTRACT: Implantable flexible neural interfaces (IfNIs) are capable of directly modulating signals of the central and peripheral nervous system by stimulating or recording the action potential. Despite outstanding results in acute experiments on animals and humans, their long-term biocompatibility is hampered by the effects of foreign body reactions that worsen electrical performance and cause tissue damage. We report on the fabrication of a polysaccharide nanostructured thin film as a coating of polyimide (PI)-based IfNIs. The layer-by-layer technique was used to coat the PI surface due to its versatility and ease of manufacturing. Two different LbL deposition techniques were tested and compared: dip coating and spin coating. Morphological and physiochemical characterization showed the presence of

SUBMITTER: Redolfi Riva E 

PROVIDER: S-EPMC9146946 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature