Early Metabolomic Markers of Acute Low-Dose Exposure to Uranium in Rats.

ABSTRACT: Changes in metabolomics over time were studied in rats to identify early biomarkers and highlight the main metabolic pathways that are significantly altered in the period immediately following acute low-dose uranium exposure. A dose response relationship study was established from urine and plasma samples collected periodically over 9 months after the exposure of young adult male rats to uranyl nitrate. LC-MS and biostatistical analysis were used to identify early discriminant metabolites. As expected, low doses of uranium lead to time-based non-toxic biological effects, which can be used to identify early and delayed markers of exposure in both urine and plasma samples. A combination of surrogate markers for uranium exposure was validated from the most discriminant early markers for makin

SUBMITTER: Grison S 

PROVIDER: S-EPMC9147032 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature