The Influence of Short Motifs on the Anticancer Activity of HB43 Peptide.

ABSTRACT: Despite the remarkable similarity in amino acid composition, many anticancer peptides (ACPs) display significant differences in terms of activity. This strongly suggests that particular relative dispositions of amino acids (motifs) play a role in the interaction with their biological target, which is often the cell membrane. To better verify this hypothesis, we intentionally modify HB43, an ACP active against a wide variety of cancers. Sequence alignment of related ACPs by ADAPTABLE web server highlighted the conserved motifs that could be at the origin of the activity. In this study, we show that changing the order of amino acids in such motifs results in a significant loss of activity against colon and breast cancer cell lines. On the contrary, amino acid substitution in key motifs may r

SUBMITTER: Herrera-Leon C 

PROVIDER: S-EPMC9147034 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature