Chromene Derivatives as Selective TERRA G-Quadruplex RNA Binders with Antiproliferative Properties.

ABSTRACT: In mammalian cells, telomerase transcribes telomeres in large G-rich non-coding RNA, known as telomeric repeat-containing RNA (TERRA), which folds into noncanonical nucleic acid secondary structures called G-quadruplexes (G4s). Since TERRA G4 has been shown to be involved in telomere length and translation regulation, it could provide valuable insight into fundamental biological processes, such as cancer growth, and TERRA G4 binders could represent an innovative strategy for cancer treatment. In this work, the three best candidates identified in our previous virtual screening campaign on bimolecular DNA/RNA G4s were investigated on the monomolecular Tel DNA and TERRA G4s by means of molecular modelling simulations and in vitro and in cell analysis. The results obtained in this work highlig

SUBMITTER: Rocca R 

PROVIDER: S-EPMC9147070 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature