Ageing- and AAA-associated differentially expressed proteins identified by proteomic analysis in mice.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA) is a disease of high prevalence in old age, and its incidence gradually increases with increasing age. There were few studies about differences in the circulatory system in the incidence of AAA, mainly because younger patients with AAA are fewer and more comorbid nonatherosclerotic factors.

Method

We induced AAA in ApoE^-/- male mice of different ages (10 or 24 weeks) and obtained plasma samples. After the top 14 most abundant proteins were detected, the plasma was analyzed by a proteomic study using the data-dependent acquisition (DDA) technique. The proteomic results were compared between different groups to identify age-related differentially expressed proteins (DEPs) in the circulation that contribute to AAA formation.

SUBMITTER: Ren J 

PROVIDER: S-EPMC9147329 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature