Integrative analysis of transcriptome complexity in pig granulosa cells by long-read isoform sequencing.

ABSTRACT:

Background

In intensive and large-scale farms, abnormal estradiol levels in sows can cause reproductive disorders. The high incidence rate of reproductive disturbance will induce the elimination of productive sows in large quantities, and the poor management will bring great losses to the pig farms. The change in estradiol level has an important effect on follicular development and estrus of sows. To solve this practical problem and improve the productive capacity of sows, it is significant to further clarify the regulatory mechanism of estradiol synthesis in porcine granulosa cells (GCs). The most important function of granulosa cells is to synthesize estradiol. Thus, the studies about the complex transcriptome in porcine GCs are significant. As for precursor-messenger RNAs (pre-m

SUBMITTER: Li S 

PROVIDER: S-EPMC9147391 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature