Metabolic Profile and Metabolite Analyses in Extreme Weight Responders to Gastric Bypass Surgery.

ABSTRACT:

Background

Roux-en-Y gastric bypass (RYGB) surgery belongs to the most frequently performed surgical therapeutic strategies against adiposity and its comorbidities. However, outcome is limited in a substantial cohort of patients with inadequate primary weight loss or considerable weight regain. In this study, gut microbiota composition and systemically released metabolites were analyzed in a cohort of extreme weight responders after RYGB.

Methods

Patients (n = 23) were categorized based on excess weight loss (EWL) at a minimum of two years after RYGB in a good responder (EWL 93 ± 4.3%) or a bad responder group (EWL 19.5 ± 13.3%) for evaluation of differences in metabolic outcome, eating behavior and gut microbiota taxonomy and metabolic activity.

Results

Mean B

SUBMITTER: Fries CM 

PROVIDER: S-EPMC9147451 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature