Holter Recordings at Initial Assessment for Long QT Syndrome: Relationship to Genotype Status and Cardiac Events.

ABSTRACT:

Background

The relationship of Holter recordings of repolarization length to outcome in long QT syndrome (LQTS) is unknown.

Methods

Holter recordings and initial 12 lead ECG QTc were related to outcome in 101 individuals with LQTS and 28 gene-negative relatives. Mean QTc (mQTc) and mean RTPc (R-wave to peak T-wave, mRTPc) using Bazett correction were measured, analyzing heart rates 40 to 120 bpm. Previously reported upper limit of normal (ULN) were: women and children (<15 years), mQTc 454, mRTPc 318 ms; men mQTc 446 ms, mRTPc 314 ms.

Results

Measurements in LQTS patients were greatly prolonged; children and women mean mQTc 482 ms (range 406-558), mRTPc 351 ms (259-443); males > 15 years mQTc 469 ms (407-531), mRTPc 338 ms (288-388). Ten patients had cardiac arr

SUBMITTER: Waddell-Smith KE 

PROVIDER: S-EPMC9147587 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature