Intrapersonal Stability of Plasma Metabolomic Profiles over 10 Years among Women.

ABSTRACT: In epidemiological studies, samples are often collected long before disease onset or outcome assessment. Understanding the long-term stability of biomarkers measured in these samples is crucial. We estimated within-person stability over 10 years of metabolites and metabolite features (n = 5938) in the Nurses' Health Study (NHS): the primary dataset included 1880 women with 1184 repeated samples donated 10 years apart while the secondary dataset included 1456 women with 488 repeated samples donated 10 years apart. We quantified plasma metabolomics using two liquid chromatography mass spectrometry platforms (lipids and polar metabolites) at the Broad Institute (Cambridge, MA, USA). Intra-class correlations (ICC) were used to estimate long-term (10 years) within-person stability of met

SUBMITTER: Zeleznik OA 

PROVIDER: S-EPMC9147746 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature