Proteoglycans: Systems-Level Insight into Their Expression in Healthy and Diseased Placentas.

ABSTRACT: Proteoglycan macromolecules play key roles in several physiological processes (e.g., adhesion, proliferation, migration, invasion, angiogenesis, and apoptosis), all of which are important for placentation and healthy pregnancy. However, their precise roles in human reproduction have not been clarified. To fill this gap, herein, we provide an overview of the proteoglycans' expression and role in the placenta, in trophoblast development, and in pregnancy complications (pre-eclampsia, fetal growth restriction), highlighting one of the most important members of this family, syndecan-1 (SDC1). Microarray data analysis showed that of 34 placentally expressed proteoglycans, SDC1 production is markedly the highest in the placenta and that SDC1 is the most upregulated gene duri

SUBMITTER: Oravecz O 

PROVIDER: S-EPMC9147780 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature