Development of Jelly Loaded with Nanogel Containing Natural L-Dopa from Mucuna pruriens Seed Extract for Neuroprotection in Parkinson's Disease.

ABSTRACT: The first line therapy of patients with Parkinson's disease, a neurodegenerative disorder caused by the degeneration of dopaminergic neurons, is levodopa (L-dopa) given orally. Recently, the presence of natural L-dopa in the seed of Mucuna pruriens, a tropical legume in the Fabaceae family, was reported and it showed superior efficiency compared with synthetic L-dopa. Therefore, this study aimed to examine the phytochemical compounds, particularly for natural L-dopa, in M. pruriens seed extract and subsequently prepare a nanogel containing the extract prior to incorporation into a jelly formulation for use as a functional food in elderly patients with Parkinson's disease. The results show that M. pruriens seed extract contains phenolic compounds, flavonoids, tannins, a

SUBMITTER: Chittasupho C 

PROVIDER: S-EPMC9147856 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature