Effects of glucose and blood pressure reduction on subclinical cardiac damage: Results from ADVANCE.

ABSTRACT:

Objective

Observational data suggest a potential for subclinical cardiac damage from intensive blood glucose or blood pressure (BP) control, particularly in adults with very low blood glucose and BP levels. However, this has not been tested in a randomized trial.

Methods

The Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Research Controlled Evaluation (ADVANCE) study was a factorial, randomized trial designed to test the effects of intensive blood glucose (hemoglobin A1c ≤6.5% versus usual care) and intensive BP (combination of perindopril-indapamide versus placebo) control on vascular events in adults with diabetes. Using mixed effects tobit models, we determined the effect of the randomized interventions on change in subclinical cardiac injury (hi

SUBMITTER: Juraschek SP 

PROVIDER: S-EPMC9148188 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature