Identification of biotypes in Attention-Deficit/Hyperactivity Disorder, a report from a randomized, controlled trial.

ABSTRACT: Attention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous disorder. Current subtypes lack longitudinal stability or prognostic utility. We aimed to identify data-driven biotypes using multiple cognitive measures, then to validate these biotypes using EEG, ECG, and clinical response to atomoxetine as external validators. Study design was a double-blind, randomized, placebo-controlled crossover trial of atomoxetine including 116 subjects ages 6 through 17 with diagnosis of ADHD and 56 typically developing controls. Initial features for unsupervised machine learning included a cognitive battery with 20 measures affected in ADHD. External validators included baseline mechanistic validators (using electroencephalogram/EEG and electrocardiogram/ECG) and clinical response (ADHD Rating Sc

SUBMITTER: Leikauf JE 

PROVIDER: S-EPMC9148272 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature