MGluR5 ablation leads to age-related synaptic plasticity impairments and does not improve Huntington's disease phenotype.

ABSTRACT: Glutamate receptors, including mGluR5, are involved in learning and memory impairments triggered by aging and neurological diseases. However, each condition involves distinct molecular mechanisms. It is still unclear whether the mGluR5 cell signaling pathways involved in normal brain aging differ from those altered due to neurodegenerative disorders. Here, we employed wild type (WT), mGluR5^-/-, BACHD, which is a mouse model of Huntington's Disease (HD), and mGluR5^-/-/BACHD mice, at the ages of 2, 6 and 12 months, to distinguish the mGluR5-dependent cell signaling pathways involved in aging and neurodegenerative diseases. We demonstrated that the memory impairment exhibited by mGluR5^-/- mice is accompanied by massive neuronal loss and decreased dendritic spi

SUBMITTER: de Souza JM 

PROVIDER: S-EPMC9148310 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature