Neurodevelopmental Outcomes in Preterm Children with Sickle Cell Disease.

ABSTRACT:

Objectives

To explore the combined effect of pediatric sickle cell disease (SCD) and preterm birth on cognitive functioning.

Methods

Cognitive functioning was examined in children ages 6-8 with high risk SCD genotypes born preterm (n = 20) and full-term (n = 59) and lower risk SCD genotypes/no SCD born preterm (n = 11) and full-term (n = 99) using tests previously shown to be sensitive to SCD-related neurocognitive deficits. Factorial ANOVAs and log linear analyses were conducted to examine the relationship between SCD risk, preterm birth status, and cognitive outcomes. Continuous scores were examined for specific tests. Children were categorized as having an abnormal screening outcome if at least one cognitive score was ≥1.5 standard deviations b

SUBMITTER: Bills SE 

PROVIDER: S-EPMC9148381 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature