Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults.

ABSTRACT:

Background

Cigarette smoke is a major public health concern. Epigenetic aging may be an important pathway by which exposure to cigarette smoke affects health. However, little is known about how exposure to smoke at different life stages affects epigenetic aging, especially in older adults. This study examines how three epigenetic aging measures (GrimAge, PhenoAge, and DunedinPoAm38) are associated with parental smoking, smoking in youth, and smoking in adulthood, and whether these epigenetic aging measures mediate the link between smoke exposure and morbidity and mortality. This study utilizes data from the Health and Retirement Study (HRS) Venous Blood Study (VBS), a nationally representative sample of US adults over 50 years old collected in 2016. 2978 participants with data on e

SUBMITTER: Klopack ET 

PROVIDER: S-EPMC9148451 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature