Elaborate design of shell component for manipulating the sustained release behavior from core-shell nanofibres.

ABSTRACT:

Background

The diversified combination of nanostructure and material has received considerable attention from researchers to exploit advanced functional materials. In drug delivery systems, the hydrophilicity and sustained-release drug properties are in opposition. Thus, difficulties remain in the simultaneous improve sustained-release drug properties and increase the hydrophilicity of materials.

Methods

In this work, we proposed a modified triaxial electrospinning strategy to fabricate functional core-shell fibres, which could elaborate design of shell component for manipulating the sustained-release drug. Cellulose acetate (CA) was designed as the main polymeric matrix, whereas polyethylene glycol (PEG) was added as a hydrophilic material in the middle layer. Cur, as a mod

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9148457 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature