Dual-functional alginate and collagen-based injectable hydrogel for the treatment of cancer and its metastasis.

ABSTRACT:

Background

Immunotherapies have been gaining attention for the prevention of cancer recurrence and metastasis. Cancer immunotherapy can induce memory cells to target cancer-specific antigens and, thus, selectively kill cancer cells. However, there are difficulties in inducing cancer antigen-specific immunity due to limited knowledge regarding cancer antigens. In this study, we synthesized a dual-functional hydrogel to induce antigen generation and immune activation.

Results

To elicit a cancer self-antigen-specific immune response, we synthesized an alginate-collagen-based injectable hydrogel, called thermally responsive hydrogel (pTRG), which was incorporated with indocyanine green and the immune stimulator polyinosinic:polycytidylic acid (poly I:C). pTRG was evaluated for i

SUBMITTER: Hwang J 

PROVIDER: S-EPMC9148466 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature