Rebooting life: engineering non-natural nucleic acids, proteins and metabolites in microorganisms.

ABSTRACT: The surging demand of value-added products has steered the transition of laboratory microbes to microbial cell factories (MCFs) for facilitating production of large quantities of important native and non-native biomolecules. This shift has been possible through rewiring and optimizing different biosynthetic pathways in microbes by exercising frameworks of metabolic engineering and synthetic biology principles. Advances in genome and metabolic engineering have provided a fillip to create novel biomolecules and produce non-natural molecules with multitude of applications. To this end, numerous MCFs have been developed and employed for production of non-natural nucleic acids, proteins and different metabolites to meet various therapeutic, biotechnological and industrial applications. The pres

SUBMITTER: Hans S 

PROVIDER: S-EPMC9148472 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature