Regulatory mechanism of Haa1p and Tye7p in Saccharomyces cerevisiae when fermenting mixed glucose and xylose with or without inhibitors.

ABSTRACT:

Background

Various inhibitors coexist in the hydrolysate derived from lignocellulosic biomass. They inhibit the performance of Saccharomyces cerevisiae and further restrict the development of industrial bioethanol production. Transcription factors are regarded as targets for constructing robust S. cerevisiae by genetic engineering. The tolerance-related transcription factors have been successively reported, while their regulatory mechanisms are not clear. In this study, we revealed the regulation mechanisms of Haa1p and Tye7p that had outstanding contributions to the improvement of the fermentation performance and multiple inhibitor tolerance of S. cerevisiae.

Results

Comparative transcriptomic analyses were applied to reveal the regulatory mechanisms of Haa1p and Tye7p unde

SUBMITTER: Li B 

PROVIDER: S-EPMC9148474 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature