Regeneration of meniscal avascular zone using autogenous meniscal fragments in a rabbit model.

ABSTRACT:

Background

To investigate the effects of autologous meniscus fragment (AMF) implantation on injury in the meniscal avascular zone in mature rabbits.

Methods

Adult New Zealand white rabbits were randomly divided into two groups. Massive one-piece meniscus tissue was implanted in situ as control. In the experimental group, AMF was used to repair the meniscal injury in the avascular zone. Meniscal damage was assessed by gross observation of the degree of healing and histological semi-quantitative evaluation within 12 weeks postoperatively. The healing of meniscus interface was assessed by gross observation semiquantitative scoring and microscopic examination hematoxylin and eosin (H&E) staining at 2, 4, 8, and 12 weeks after surgery. The expressions of proliferating cell nuclea

SUBMITTER: Deng Y 

PROVIDER: S-EPMC9148493 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature