Measures of high-density lipoprotein function in men and women with severe aortic stenosis.

ABSTRACT:

Background

Calcification of the aortic valve is a common heart valve disorder, in some cases leading to clinically impactful severe aortic stenosis (AS). Sex-specific differences in aortic valve calcification (ACV) exist, with women having a lower burden of calcification than men as measured by computed tomography; however, the pathophysiological mechanism that leads to these differences remains unclear.

Methods

Using cultured human Tamm-Horsfall protein 1 (THP-1) macrophages and human aortic valve interstitial cells, the effects of high-density lipoprotein (HDL) particles isolated from the plasma of men and women with severe AS were studied for cholesterol efflux capacity (CEC).

Results

HDL-CEC was assessed in 46 patients with severe AS, n = 30 men, n = 16 women. ATP

SUBMITTER: Hafiane A 

PROVIDER: S-EPMC9148512 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature