Optimization of the production process for the anticancer lead compound illudin M: improving titers in shake-flasks.

ABSTRACT:

Background

The fungal sesquiterpenes Illudin M and S are important base molecules for the development of new anticancer agents due to their strong activity against some resistant tumor cell lines. Due to nonspecific toxicity of the natural compounds, improvement of the pharmacophore is required. A semisynthetic derivative of illudin S (Irofulven) entered phase II clinical trials for the treatment of castration-resistant metastatic prostate cancer. Several semisynthetic illudin M derivatives showed increased in vitro selectivity and improved therapeutic index against certain tumor cell lines, encouraging further investigation. This requires a sustainable supply of the natural compound, which is produced by Basidiomycota of the genus Omphalotus. We aimed to develop a robust biotechno

SUBMITTER: Chaverra-Munoz L 

PROVIDER: S-EPMC9148526 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature