Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study.

ABSTRACT:

Background

The clinical heterogeneity of COVID-19 suggests the existence of different phenotypes with prognostic implications. We aimed to analyze comorbidity patterns in critically ill COVID-19 patients and assess their impact on in-hospital outcomes, response to treatment and sequelae.

Methods

Multicenter prospective/retrospective observational study in intensive care units of 55 Spanish hospitals. 5866 PCR-confirmed COVID-19 patients had comorbidities recorded at hospital admission; clinical and biological parameters, in-hospital procedures and complications throughout the stay; and, clinical complications, persistent symptoms and sequelae at 3 and 6 months.

Findings

Latent class analysis identified 3 phenotypes using training and test subcohorts: low-morbidity (n=

SUBMITTER: Benitez ID 

PROVIDER: S-EPMC9148543 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature