Characterization of the diffusion signal of breast tissues using multi-exponential models.

ABSTRACT:

Purpose

Restriction spectrum imaging (RSI) decomposes the diffusion-weighted MRI signal into separate components of known apparent diffusion coefficients (ADCs). The number of diffusion components and optimal ADCs for RSI are organ-specific and determined empirically. The purpose of this work was to determine the RSI model for breast tissues.

Methods

The diffusion-weighted MRI signal was described using a linear combination of multiple exponential components. A set of ADC values was estimated to fit voxels in cancer and control ROIs. Later, the signal contributions of each diffusion component were estimated using these fixed ADC values. Relative-fitting residuals and Bayesian information criterion were assessed. Contrast-to-noise ratio between cancer and fibroglandular tissu

SUBMITTER: Rodriguez-Soto AE 

PROVIDER: S-EPMC9148547 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature