The extra-embryonic space and the local contour are crucial geometric constraints regulating cell arrangement.

ABSTRACT: In multicellular systems, cells communicate with adjacent cells to determine their positions and fates, an arrangement important for cellular development. Orientation of cell division, cell-cell interactions (i.e. attraction and repulsion) and geometric constraints are three major factors that define cell arrangement. In particular, geometric constraints are difficult to reveal in experiments, and the contribution of the local contour of the boundary has remained elusive. In this study, we developed a multicellular morphology model based on the phase-field method so that precise geometric constraints can be incorporated. Our application of the model to nematode embryos predicted that the amount of extra-embryonic space, the empty space within the eggshell that is not occupied by embryonic

SUBMITTER: Seirin-Lee S 

PROVIDER: S-EPMC9148568 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature