Both entry to and exit from diapause arrest in Caenorhabditis elegans are regulated by a steroid hormone pathway.

ABSTRACT: Diapause arrest in animals such as Caenorhabditis elegans is tightly regulated so that animals make appropriate developmental decisions amidst environmental challenges. Fully understanding diapause requires mechanistic insight of both entry and exit from the arrested state. Although a steroid hormone pathway regulates the entry decision into C. elegans dauer diapause, its role in the exit decision is less clear. A complication to understanding steroid hormonal regulation of dauer has been the peculiar fact that steroid hormone mutants such as daf-9 form partial dauers under normal growth conditions. Here, we corroborate previous findings that daf-9 mutants remain capable of forming full dauers under unfavorable growth conditions and establish that the daf-9 partial dauer state is likely a

SUBMITTER: Zhang MG 

PROVIDER: S-EPMC9148571 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature