Expression of Maf family proteins in glutamatergic neurons of the mouse olfactory bulb.

ABSTRACT: The fate of neurons in the developing brain is largely determined by the combination of transcription factors they express. In particular, stem cells must follow different transcriptional cascades during differentiation in order to generate neurons with different neurotransmitter properties, such as glutamatergic and GABAergic neurons. In the mouse cerebral cortex, it has been shown that large Maf family proteins, MafA, MafB and c-Maf, regulate the development of specific types of GABAergic interneurons but are not expressed in glutamatergic neurons. In this study, we examined the expression of large Maf family proteins in the developing mouse olfactory bulb (OB) by immunohistochemistry and found that the cell populations expressing MafA and MafB are almost identical, and most of them expr

SUBMITTER: Ito A 

PROVIDER: S-EPMC9148588 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature