Diurnal rhythms in cholinergic modulation of rapid dopamine signals and associative learning in the striatum.

ABSTRACT: Dysregulation of biological rhythms plays a role in a wide range of psychiatric disorders. We report mechanistic insights into the rhythms of rapid dopamine signals and cholinergic interneurons (CINs) working in concert in the rodent striatum. These rhythms mediate diurnal variation in conditioned responses to reward-associated cues. We report that the dopamine signal-to-noise ratio varies according to the time of day and that phasic signals are magnified during the middle of the dark cycle in rats. We show that CINs provide the mechanism for diurnal variation in rapid dopamine signals by serving as a gain of function to the dopamine signal-to-noise ratio that adjusts across time of day. We also show that conditioned responses to reward-associated cues exhibit diurnal rhythms, with cue-dir

SUBMITTER: Stowe TA 

PROVIDER: S-EPMC9148619 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature